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Contribution of Body Composition and Resting Metabolic Rate to Bone Mineral Density in Women 17 – 78 Years of Age
Author(s) -
Andreoli Angela,
Volpe Stella Lucia,
Van Loan Marta,
Di Daniele Nicola,
Iacopino Leonardo,
De Lorenzo Antonino
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.332.4
Objective Although obesity has been shown to increase bone mineral density (BMD) and perhaps prevent osteoporosis, its risks for other chronic diseases may outweigh the benefits on BMD. The primary objective of this study was to correlate body composition (BC) and resting metabolic rate (RMR) with bone mineral density (BMD) and to develop models to evaluate the contribution of BC and RMR to BMD. Design cross‐sectional study evaluating BMD, BC, and RMR. Participants Women 17 – 78 years of age (n=420) underwent BC, RMR and BMD measurements (fat mass, trunk fat mass, and total LBM, trunk and leg LBM). BC and BMD were determined by Dual Energy X‐ray Absorptiomety (DXA). RMR was measured by indirect calorimetry on a subset of 281. Results Significant correlations were found between BMD, BC, and RMR for total body, spine, and pelvis BMD. Stepwise multiple regression models showed that RMR was the most important contributor to BMD at all 3 bone sites and accounted for 17.5% – 28.9% of the variance in BMD across sites. Conclusions These data demonstrate the importance of adequate metabolic rate through out the lifespan for maintenance of BMD. Age related decline in BMD may be attenuated if metabolic rate is maintained; suggesting the importance of an active lifestyle as one ages.