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Oxidative stress markers in Russian overweight subjects and its relationship with cardiovascular risk
Author(s) -
Tutelyan Victor Alexandrovich,
Kaganov Boris S,
Isakov Vasily A,
Zeigarnik M V,
Silvestrova Galina A,
Golubeva Alexsandra A,
Lin Yumei,
Petrenko Alexey,
Dudnikova Anastasiya,
Samuylova Elena
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.331.8
Subject(s) - overweight , oxidative stress , medicine , environmental health , obesity
Study objective was to assess the relationship between oxidative stress markers and cardiovascular risk in overweight Russia adults. Blood glutathione peroxidase (GSHPx), superoxide dismutases (SOD), malondialdehyde (MDA) and urinary 8‐oxo‐2′‐deoxyguanosine (8‐oxo‐dG) were determined in 100 established cardiovascular disease subjects (CVD group) and 100 individuals (control group). Significant difference in BMI (CVD 34.2 ± 9.4 vs. control 27.5 ± 5.0) was found. Significantly higher blood MDA (2.12 ± 0.81 vs. 1.86 ± 0.82 nmol/ml, p=0,025) and urinary 8‐oxo‐dG (0.000018 vs. 0.000013 uM/ml, p<0.0001) were also observed in CVD group as compared to control group. Interestingly, there was no difference in SOD and GSHPx between groups. All above‐mentioned marker levels were sex and age independent in both groups. Among the blood chemistry results, only glucose (5.49 [Q25–75%: 5.18–6.08] vs. 5.10 [4.76–5.61] mmol/l, p <0.0001) and uric acid (351.04 ± 115.59 vs. 272.60 ± 98.08 mmol/l, p<0.0001) levels were found to be related with CVD risk. More patients from CVD group demonstrated hyperuricemia (48 vs. 18, p=0.00003). Detailed analysis revealed that blood urea acid level was highly correlated with BMI and CVD risk in CVD patients, but not in control subjects. In conclusion, CVD patients demonstrated higher oxidative stress than control subjects, as well as more hyperuricemia incidence, which was correlated with their BMI.