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The processing of wheat bran to release bound phenolic compounds improves insulin resistance and reduces visceral adiposity and liver cholesterol in ZDF rat
Author(s) -
Youn Moonyeon,
Csallany A. Saari,
Gallaher Daniel D.
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.329.4
Subject(s) - insulin resistance , medicine , chemistry , bioavailability , endocrinology , excretion , cholesterol , bran , basal (medicine) , insulin , biochemistry , biology , pharmacology , raw material , organic chemistry
Wheat bran (WB) is a rich source of potentially bioactive phenolic compounds but which are largely unavailable. The aim of this study was to examine how consumption of WB processed to release bound phenolics alters metabolic parameters related to diabetes in a model of type 2 diabetes with obesity, the Zucker diabetic fatty (ZDF) rat. WB was processed with chemical treatment and high pressure homogenization to produce an optimized WB (OWB), which was further processed into soluble and insoluble fractions by physical separation. Male ZDF rats (n=10) were fed diets containing either a WB‐free basal diet or WB‐containing diets (16.4% WB, 22.9% OWB, 27% soluble fraction or 14.1% insoluble fraction) for 3 weeks. The OWB and soluble fraction diets decreased epididymal fat pad weight and increased plasma adiponectin level relative to the WB diet. Insulin resistance (IR) was improved by all processed WB diets. All WB‐containing diets decreased plasma insulin and plasma and liver cholesterol and increased bile acid excretion compared to the basal diet. However, OWB and soluble fraction diets improved IR, decreased plasma insulin and liver cholesterol, and increased bile acid excretion compared to the WB diet. These results suggest that processing of WB led to greater phenolic bioavailability which improved the diabetic condition by decreasing IR, visceral adiposity, and liver cholesterol in ZDF rat. Grant Funding Source: USDA