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Neuropilin receptors direct neural crest cell pathway choice and migratory trajectories
Author(s) -
Gammill Laura,
RoffersAgarwal Julaine,
Burt Ashleigh
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.299.2
Subject(s) - neural crest , biology , neuropilin 1 , neural fold , microbiology and biotechnology , neuroscience , cell migration , anatomy , neural plate , cell , embryo , genetics , cancer research , vascular endothelial growth factor , vegf receptors
Neural crest cells migrate over spatially and temporally defined pathways to form diverse structures in vertebrate embryos. Patterning migratory neural crest cell trajectories is crucial for positioning neural crest‐derived cell types. Our research aims to define the importance of Neuropilin receptors in restricting migratory neural crest cells to their spatiotemporally restricted routes. In the trunk, early waves of neural crest cells migrate ventrally, invading only anterior somites in a segmental fashion. Later, neural crest cells migrate dorsolaterally, between the somites and epidermis. We have shown that the receptor Neuropilin2 (Nrp2) and its repulsive ligand Semaphorin3F (Sema3F) are essential for segmental neural crest migration. We have further shown that the related receptor/ligand pair Nrp1/Sema3A is required for subsequent segmental condensation of the resulting neural crest‐derived metameric dorsal root ganglia. In analyzing this requirement, we noted that neural crest cells enter the dorsolateral pathway prematurely in Nrp1 Sema3A mutant mice. We have gone on to better define the timing of dorsolateral neural crest migration in the mouse, and the role of Nrp1 in dorsolateral pathway choice. This work was supported by NIH K22 DE015309.