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Ultra high viscosity hydroxypropylmethylcellulose blunts postprandial glucose after a breakfast meal
Author(s) -
Gee David L.,
Dow Shireen,
Pritchett Kelly L,
Hawk Susan,
Herrington Stefanie J.
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.29.8
Subject(s) - postprandial , crossover study , meal , psyllium , placebo , food science , area under the curve , medicine , chemistry , dietary fiber , zoology , endocrinology , diabetes mellitus , biology , alternative medicine , pathology
The effects of two water soluble dietary fibers, ultra‐high‐viscosity hydroxypropylmethylcellulose (UHV‐HPMC, non‐fermentable) and psyllium fiber (fermentable), on postprandial glucose and second meal effects in 13 healthy adults were studied. In a single blind crossover design, subjects were given standardized pre‐measured breakfast and lunch meals with either 4 g of the fiber supplements or a placebo. Blood glucose was measured with a continuous blood glucose monitoring system (DexCom Seven Plus, San Diego, CA). Subjects consuming UHV‐HPMC had significantly (P < 0.05) lower blood glucose area under the curve (AUC) two hours after breakfast then those receiving a placebo. Albeit not significant ( P = 0.07), subjects consuming psyllium tended to have lower glucose levels than the placebo group. Peak glucose concentration following breakfast was significantly ( P < 0.01) less with both UHV‐HPMC and psyllium when compared to the placebo. The glucose lowering effect of these dietary fiber supplements appeared to be greater in those subjects who habitually consumed little dietary fiber. There were no significant differences in AUC or peak glucose concentration between treatments following the second meal (lunch) suggesting no residual effect from the fiber supplements.