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Low Vitamin D Status is Associated with Increased Adiposity and Ethnicity
Author(s) -
Sulistyoningrum Dian C,
Green Timothy J,
Lear Scott A,
Devlin Angela M
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.223.4
Subject(s) - vitamin d and neurology , adipose tissue , medicine , vitamin d deficiency , endocrinology , body fat distribution , ethnic group , population , physiology , demography , environmental health , sociology , anthropology
Previous studies have shown that vitamin D deficiency, a risk factor for cardiovascular disease, is prevalent in obese individuals. Vitamin D status is dependent on sun exposure, age, sex, skin color, and body fat distribution. The Multicultural‐Community Health Assessment Trial (M‐CHAT) showed that ethnicity predicts body fat distribution with greater visceral adipose tissue (VAT) per kg of body fat in South Asians compared to Europeans. The goal of this study is to investigate if serum 25‐hydroxyvitamin D3 [25(OH)D] is associated with body fat deposition in 187 European and 192 South Asian MCHAT subjects. South Asians had lower (P<0.001) levels of 25(OH)D than Europeans. Using regression models adjusted for ethnicity, 25(OH)D was inversely associated with season, percent body fat, HOMA‐IR and age (P< 0.05). Following further adjustment for body fat distribution serum 25(OH)D was inversely associated with VAT (P<0.001) but not subcutaneous adipose tissue (SAT). When VAT and SAT were included in the same model, the relationship of serum 25(OH)D with VAT remained (P = 0.001) and there was no relationship with SAT. Similar results were also found when Europeans and South Asians were analyzed separately. These findings show that vitamin D levels are strongly associated with VAT deposition and are lower in South Asians further contributing to the elevated risk for cardiovascular disease in this population. Grant Funding Source : Canadian Institutes for Health Research