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BMI is not a risk factor for medically attended influenza
Author(s) -
Coleman Laura,
Waring Stephen,
Irving Stephanie,
Meece Jennifer,
Shay David,
Belongia Edward
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.222.2
Subject(s) - medicine , logistic regression , pandemic , obesity , population , vaccination , covid-19 , pediatrics , demography , immunology , environmental health , disease , infectious disease (medical specialty) , sociology
Background Obesity may impair immune response to influenza infection. We evaluated whether medically attended, rRT‐PCR‐confirmed influenza was independently associated with BMI in a central Wisconsin population. Methods Adults ≥ 20 yrs with acute respiratory illness were recruited during the 2007–08 season (n=903), 2008–09 season (n=869), and 2009 pandemic (n=851). Nasopharyngeal swabs were tested for influenza by rRT‐PCR. BMI was calculated with data from electronic medical records (any adult height and weight 30 days +/− enrollment). Logistic regression evaluated the association between rRT‐PCR confirmed influenza and BMI, adjusting for sex, vaccination, age, and high risk condition. Results Influenza was detected in 453/903 patients in 2007–08, 131/869 patients in 2008–09, and 119/851 patients during the pandemic. Predominant seasonal viruses were A/H3N2 in 2007–08, and A/H1N1 and B in 2008–09. Mean (SD) BMI was 30.58 (7.31) in patients with influenza and 30.93 (7.55) in controls across all seasons. Mean BMI of patients with influenza did not vary by season. In adjusted logistic regression models, BMI did not predict influenza in 2007–08 (OR 1.00, 95% CI 0.986–1.023), 2008–09 (OR 0.98, 95% CI 0.96–1.01), or 2009 pandemic (OR 1.00, 95% CI 0.974–1.028). Conclusion BMI was not independently associated with medically attended influenza in adults in this population. Funding ‐ CDC grant 1 UO1 C1000192‐01