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Vitamin D supplementation increases osteocalcin but not other markers of bone turnover during short‐term caloric restriction in women
Author(s) -
SUKUMAR DEEPTHA,
SCHNEIDER STEPHEN,
AMBIASOBHAN HASINA,
SCHLUSSEL YVETTE,
SHAPSES SUE
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.218.5
Subject(s) - endocrinology , medicine , bone remodeling , osteocalcin , parathyroid hormone , n terminal telopeptide , vitamin d and neurology , glucose homeostasis , insulin resistance , insulin , chemistry , alkaline phosphatase , calcium , biochemistry , enzyme
Osteocalcin (OC) is a bone matrix gla protein and a marker of bone formation and may be influenced by vitamin D (vit D). Recent reports suggest that OC may also influence glucose homeostasis and act as a regulator of energy metabolism. Vitamin D (vit D) supplementation suppresses parathyroid hormone (PTH) levels, which may attenuate the increased bone turnover (BT) associated with caloric restriction (CR). In addition, vit D may also improve insulin sensitivity in glucose intolerant individuals. In this randomized double blind trial, we examined whether vit D supplementation has differential effects on OC compared to other BT markers in overweight/obese postmenopausal women without evidence of type 2 diabetes, during 6 weeks of CR. Women were supplemented with 2500 IU of vit D3 or placebo, and all received 1.2g of Ca. 42 women (58 ± 6 yrs, 31±4 kg/m2) completed the study and lost 4 ± 1% of weight with no differences between groups. Serum 25‐hydroxyvitamin D (25OHD) increased (7.5 ± 5.8ng/ml) in vit D group (p < 0.01). PTH, propeptide of type 1 collagen, N‐telopeptide of type 1 collagen and pyridinium cross links did not differ, whereas OC was higher in the vit D group (p<0.01). These results show that vit D supplementation during CR influences OC and not other BT markers. To what extent changes in OC are associated with improved insulin sensitivity as opposed to being a marker of bone turnover is currently being examined. Grant Funding Source : NIH‐NIA AG12161