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Intake of dairy and calcium, NSAIDs and prostate cancer aggressiveness
Author(s) -
Steck Susan E.,
Su L. Joseph,
Arab Lenore,
Fontham Elizabeth T.H.,
Bensen Jeannette,
Hebert James R.,
Zhang Hongmei,
Mohler James
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.214.6
Subject(s) - medicine , prostate cancer , logistic regression , confounding , calcium , population , cancer , environmental health
Dairy products and calcium are associated with increased risk of prostate cancer (PrCa) in some, but not all, studies. Inflammation is a potential mediator of disease aggressiveness. The associations among intakes of dairy products and calcium, use of non‐steroidal anti‐inflammatory drugs (NSAIDs) and PrCa aggressiveness were examined among African Americans and Caucasian Americans in a population‐based, case‐only study (the North Carolina‐Louisiana Prostate Cancer Project, PCaP). Low aggressive cases (n=987) were defined as Gleason sum <7 and clinical stage T1‐T2 and PSA <10 ng/ml, and high/intermediate aggressive cases (n=936) were defined as all others. Logistic regression was used to calculate ORs and 95% CIs for risk of aggressive PrCa. Dairy product intake was not associated with PrCa aggressiveness after adjusting for potential confounders. Calcium intake was positively associated with PrCa aggressiveness (OR, 1.27, 95% CI, 1.01, 1.60 for highest vs. lowest tertile of intake), which was limited to men not regularly using NSAIDs (OR, 1.73, 95% CI, 1.18, 2.54 for non‐users of NSAIDs vs. OR, 1.03, 95% CI, 0.77, 1.39 for NSAIDs users). Calcium intake, but not dairy product intake, was positively associated with PrCa aggressiveness, and this effect was mitigated by NSAIDs use, an observation that requires confirmation in future studies. Grant Sponsor: Department of Defense “DAMD 17‐03‐2‐0052”