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Metabolic Syndrome (MS) is Associated with Higher Prevalence of Cardiovascular Disease (CVD) and Sleep Apnea (SA), Longer Length of Hospital Stay (LOS) and Higher Re‐hospitalization Rate after Bariatric Surgery in the Longitudinal Assessment of Bariatric Surgery (LABS) Cohort
Author(s) -
Purnell Jonathan Q,
Selzer F,
Smith M,
Berk P,
Courcoulas A,
Inabnet W,
King W,
Pender J,
Pomp A,
Raum W,
Schrope B,
Steffen K,
Wolfe B,
Patterson E
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.212.7
Subject(s) - medicine , diabetes mellitus , sleep apnea , myocardial infarction , obstructive sleep apnea , prospective cohort study , metabolic syndrome , apnea , surgery , obesity , endocrinology
Objective This study determined the prevalence of MS (using NCEP criteria) in patients referred for bariatric surgery and compared baseline co‐morbid conditions and select 30‐day post‐op outcomes in those with and without MS (Non‐MS). Methods LABS is a 10‐center, prospective study of outcomes following bariatric surgery. Complete pre‐op data were available for 2358 of 2458 LABS patients. Liver size was assessed intra‐operatively. Results The prevalence of MS and Non‐MS was 77.8% and 22.2%. Compared to Non‐MS, those with MS were more likely to be men, to present with a higher prevalence of diabetes and prior cardiac events, to have enlarged livers and higher median levels of liver enzymes, a history of sleep apnea (SA), and increased LOS and re‐hospitalization rates. Characteristics of LABS subjects. Results are mean except ALT.Non‐MS (n=524) MS (n=1834) pMale (%) 14.7 23.7 <0.001 Hx Diabetes (%) 6.1 44.8 <0.001 Hx Myocardial Infarction (%) 0.9 3.9 <0.001 Hx Sleep Apnea (%) 41.8 55.6 <0.001 Enlarged liver (%) 2.7 6.9 <0.001 Median ALT (U/L) 25.0 28.0 <0.001 Mean LOS (days) 2.0 2.4 <0.001 30‐day re‐hospitalization (%) 5.0 7.6 0.04Conclusions Establishing a diagnosis of MS in severely obese patients considering bariatric surgery may help surgeons identify patients whom also have cardiovascular and pulmonary related co‐morbidities as well as are at higher risk for longer LOS and need for readmission after discharge.