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Conserved Gene Regulatory Mechanisms Controlling Cholesterol and Fat
Author(s) -
Näär Anders M.,
Walker Amy K.,
Yang Fajun,
NajafiShoushtari S. Hani,
Rottiers Veerle,
Kristo Fjoralba,
Li Yingxia,
Shioda Toshi,
Cohen David E.,
Gerszten Robert E.
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.193.1
Subject(s) - sterol regulatory element binding protein , transcription factor , gene , sterol , lipid metabolism , microbiology and biotechnology , cholesterol , biology , energy homeostasis , homeostasis , regulation of gene expression , regulator gene , microrna , biochemistry , receptor
Proper coordination of cholesterol/lipid biosynthesis, trafficking, and degradation is essential to human health. The sterol regulatory element–binding proteins (SREBPs) are key transcription regulators of genes involved in cholesterol/lipid biosynthesis and uptake. However, it has remained unclear how SREBP‐dependent gene regulatory processes are integrated with other cellular pathways controlling metabolism and energy homeostasis. We will present studies revealing novel networks involving SREBPs, sirtuins and microRNAs that modulate conserved gene regulatory circuits governing sterol/lipid homeostasis in metazoans. Our findings support the therapeutic targeting of regulatory nodes in these networks in ameliorating cardiometabolic disorders. This research was supported by NIH grants R01DK078332, R01GM071449, and R21DK084459.