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Neural crest and cardiac development
Author(s) -
Epstein Jonathan A
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.176.4
Subject(s) - neural crest , digeorge syndrome , heart development , biology , neuroscience , disease , heart disease , neural tube , tbx1 , anatomy , microbiology and biotechnology , medicine , embryo , embryonic stem cell , genetics , gene , gene expression , promoter
Neural crest derivatives contribute to many organs and tissues throughout the body, including components of the cardiovascular system. Deficiencies of neural crest can lead to predictable forms or congenital heart disease characterized by abnormal patterning of the aortic arch arteries and defective septation of the outflow tract of the heart. Fate‐mapping studies using genetic tools in mice have helped to elucidate the developmental paths and relationships of cardiac neural crest, and to identify specific functional defects induced by genetic and environmental perturbation. Signaling pathways that modify tissue‐tissue interactions with neighboring cells are emerging, and help to explain genetic disorders in humans such as DiGeorge syndrome, Alagille syndrome and others. Emerging insights into signaling pathways regulating cardiac neural crest development will be discussed with relevance to human congenital cardiovascular disease.