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Effects of Prunella vulgaris in high glucose‐induced vascular dysfunction
Author(s) -
Hwang Sun Mi,
Lee Yun Jung,
Lee So Min,
Yoon Jung Joo,
Kim Jin Sook,
Kang Dae Gill,
Lee Ho Sub
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1115.23
Subject(s) - prunella vulgaris , chemistry , diabetes mellitus , protein kinase b , inflammation , matrix metalloproteinase , transcription factor , enos , medicine , endocrinology , phosphorylation , cancer research , biochemistry , enzyme , pathology , alternative medicine , traditional chinese medicine , nitric oxide synthase , gene
Vascular inflammation is an important factor which can promote diabetic complications. In the present study, we designed to examine the inhibitory effects of high glucose (HG)‐induced vascular dysfunction by aqueous extract from Prunella vulgaris (APV) in HUVECs and HASMCs. We found that pretreatment with APV decreased HG‐induced expression of CAMs, MMPs, and adhesion of HL‐60 monocytic cells on HUVECs. A further analysis indicated that APV attenuated HG‐induced translocation and transcription activity in p65 NF‐κB signaling pathway. Pretreatment with APV significantly inhibited the formation of intracellular ROS. Additionally, APV‐induced Akt phosphorylation could obviously increase not only the induced activation of HO‐1 and eNOS but also transcription factor Nrf2. Further, in this study, [ 3 H]‐thymidine incorporation was significantly increased compared with control and this increase was decreased by APV. Migration and invasion assay also suggested an anti‐proliferative effect of APV. This data cast a new light on the actions of Prunella vulgaris and its potential benefits to diabetic patients for preventing diabetic vascular complications.