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Effect of an Ethanol Extract of Scutellaria Baicalenisis on Penile Erection in Penile Smooth Muscle
Author(s) -
Li Xiang,
Kim Hye Yoom,
Kho Joung Hyun,
Kwon Oh Jeong,
Kang Dae Gill,
Lee Ho Sub
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1115.22
Subject(s) - phenylephrine , nitric oxide , chemistry , tetraethylammonium , smooth muscle , charybdotoxin , endocrinology , in vivo , glibenclamide , vasodilation , medicine , pharmacology , amyl nitrite , basilar artery , biology , blood pressure , microbiology and biotechnology , potassium , organic chemistry , diabetes mellitus
The aim of the present study was to investigate whether an ethanol extract of Scutellaria baicalenis (ESB) augments penile erection in vitro and in vivo. In isolated endothelium‐intact rabbit corpus cavernosum preconstricted with phenylephrine, ESB relaxed penile smooth muscle in a dose‐dependent manner, which was inhibited by pretreatment with a nitric oxide synthase inhibitor, N G ‐nitro‐L‐arginine methyl ester (L‐NAME), and a soluble guanylyl cyclase (sGC) inhibitor, 1H‐[1,2,4]‐oxadiazole‐[4,3‐α]‐quinoxalin‐1‐one (ODQ). Also, ESB‐induced relaxation was significantly attenuated by pertreatment with tetraethylammonium (TEA), glibenclamide, and charybdotoxin, respectively. ESB increased cGMP levels of the rabbit corpus cavernosum in a concentration‐dependent manner, but not increased cAMP levels of the rabbit corpus cavernosum. In addition, ESB caused increase of intracavernous pressure (ICP) and area under the carve (AUC) in a dose dependent manner in SD rats. Taken together, these results suggest that ESB may be induce penile erection through the activation of penile tissue NO/cGMP system and/or K + channel in corpus cavernosum.