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Respiratory rhythm modulation by direct injection of IL‐1β into the nucleus tractus solitarius
Author(s) -
Gresham Kenneth,
Boyer Brooke,
Wilson Christopher G.
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1111.28
Subject(s) - expiration , brainstem , respiratory system , medicine , apnea , anesthesia , control of respiration , respiration , endocrinology , anatomy
Bacterial infection during pregnancy can lead to preterm labor and neurodevelopmental impairment. Preterm infants exhibit abnormal respiratory patterns including apnea, which is exacerbated by bacterial infection. Pro‐inflammatory cytokines, like interleukin‐1 beta (IL‐1β), control the immune response to infection, and an upregulation of IL‐1β expression in areas of the brainstem responsible for respiration, such as the nucleus tractus solitarius (NTS), has been observed. We tested the hypothesis that increased in IL‐1β in the NTS will alter respiratory output. We injectioned IL‐1β into the NTS in the in vitro en bloc brainstem‐spinal cord of postnatal day 1–3 rat pups. Total breath duration (T tot ; 25% and 43% increase 1.5 and 2 hours post injection) and duration of expiration (T e ; 26% and 42% increase 1.5 and 2 hours post injection) increased while breathing frequency (27% and 44% decrease) decreased when compared to control. There was no change in duration of inspiration (T i ), but the percentage of the breathing cycle accounted for by inspiration showed a decrease. These results support a role for inflammatory cytokines such as IL‐1β in modulation of central respiratory pattern generation.