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INFLUENCE OF FEMALE SEXUAL HORMONES ON EXERCISE CAPACITY AND ON CARDIOVASCULAR AUTONOMIC MODULATION
Author(s) -
Conti Filipe Fernandes,
Sanches Iris Callado,
Dias Danielle da Silva,
Brito Sebastião,
Sartori Michelle,
Irigoyen Maria Claúdia,
De Angelis Kátia
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1108.2
Subject(s) - hormone , medicine , endocrinology , modulation (music) , cardiology , physiology , physics , acoustics
Studies suggest that the oscillation of the female sex hormones due to the menstrual cycle phases can alter the cardiovascular autonomic control and the exercise capacity. Thus, the aim of this study was to compare the maximum oxygen consumption, blood pressure and cardiovascular autonomic modulation between healthy female rats in the ovulatory (OV, n = 8) and non‐ovulatory phase (NOV, n = 8) of the estrous cycle. Oxygen consumption (VO2) was measured during a maximal exercise test performed on a treadmill. The arterial pressure (AP) direct recording was performed. The cardiovascular autonomic modulation was evaluated in the time and the frequency (spectral analysis) domains. The results showed that VO2maximum (OV: 87±3 vs. NOV: 78±3 ml.kg‐1.min‐1) and exercise test duration (OV: 23±0.6 vs. NOV: 20.7±0.8 min) were higher in the ovulatory phase in comparison to non‐ovulatory phase. The mean AP(OV: 120±2 vs. NOV: 112±2 mmHg) was higher in the OV phase as compared to the NOV phase. The pulse interval (PI) variance and the cardiac sympathetic‐vagal balance were similar between groups, but the AP total variance (OV: 47±10 vs. NOV: 25±1.4 mmHg 2 ) was higher in OV phase than in NOV phase. These findings suggest that estrous cycle hormonal flutuations may induce cardio‐respiratory changes, which should be considered for more precise and specific interventions in the prevention and management of cardiovascular disease in women.