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Ada ptations of mouse skeletal muscle to chronic low‐level, high‐frequency vibration
Author(s) -
McKeehen James Nelson,
Baltgalvis Kristen A,
Call Jarrod A,
Greising Sarah M,
Novotny Susan A,
Lowe Dawn A
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1107.21
Subject(s) - isometric exercise , contractility , medicine , muscle hypertrophy , skeletal muscle , soleus muscle , endocrinology , sarcopenia , chemistry , anatomy
Low‐level, high‐frequency (LLHF) vibration creates a mechanical signal that stimulates bone formation. The objective of this study was to if determine muscle mass and contractility are improved with LLHF vibration, and if this treatment could offset decrements in muscle function associated with physical inactivity. Male C57BL/6 mice (8‐wk‐old) were divided into 4 groups using a 2×2 factorial design to study LLHF vibration and physical inactivity. Mice in the LLHF vibration groups were placed in a vibration chamber (15min/d, 5 d/wk, 45 Hz, 1 g of acceleration). Mice in the inactivity groups were housed in small cages that limited their movement (2.5 × 4.8 × 3.5″). After 6 wk of treatment, inactivity caused a small decrement in muscle strength of the anterior lower leg muscles (2.8 +/− 0.1 vs. 2.5 +/− 0.1 N*mm; p=0.017), but mice receiving the LLHF vibration treatment generated 9% more isometric torque than control mice (2.7 +/− 0.1 vs 2.5 +/− 0.1 N*mm; p=0.038). Ex vivo soleus muscle contractility showed similar results. Additionally, the rate of soleus muscle relaxation was reduced 36% with inactivity, but was 18% greater in the LLHF vibration group. Soleus, gastrocnemius, EDL, and TA muscle masses were left unchanged as a result of LLHF vibration or cage type. These results show that LLHF vibration benefits muscle function by improving muscle strength independent of hypertrophy. Supported by MDA grant 114071.