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How Developmental Programs Contribute to Tumor Development and Progression C Lessons from Drosophila.
Author(s) -
Xu Tian
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.11.1
Subject(s) - drosophila (subgenus) , biology , evolutionary biology , genetics , gene
The Xu lab develops and utilizes genetic approaches in model organisms to study disease and development. Genome‐wide genetic screens have been performed in Drosophila to identify genes that promote tumor development and progression. Fly tumors exhibit a full range of metastatic behavior similar to that observed in human malignant tumors including uncontrolled tumor growth, loss of cell adhesion, basement membrane degradation, tumor cell migration and invasion, and secondary tumor formation. Characterization of the identified genes and studies of the involved processes have revealed that tumor cells hijack developmental programs and their regulatory molecular pathways. How size control mechanism, compensatory growth, and guided cell migration contribute to tumor development and metastasis will be discussed.