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Mental Stress Exposed Novel Quantitative Trait Loci for Haemodynamics in Large Arabs Pedigrees. of “Oman Family Study”
Author(s) -
Hassan Mohammed O.,
Albarwani Sulayma,
Yahyee Said Al,
Jaju Deepali,
LopezAlvarenga Juan C.,
Commuzie Antony G.,
Bayoumi Riad
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1099.3
Subject(s) - quantitative trait locus , blood pressure , pedigree chart , cardiology , hemodynamics , genetic linkage , impedance cardiography , medicine , genetics , heart rate , biology , stroke volume , gene
Background The complexity of the interaction of genetic susceptibility and environmental determinants of hypertension are best understood by replaying the conditions that have shaped them in the first place. Objectives To perform genome‐wide linkage of primary cardiac and haemodynamic components of blood pressure (BP) under resting and stress conditions in large Arab pedigrees. Methods The Oman Family Study includes 1277 subjects recruited from five extended families of ~10 generations. In these subjects, hemodynamic phenotypes were computed from beat‐to‐beat BP, electrocardiography and impedance cardiography. Multi‐point linkage was performed for resting and during mental stress (word conflict test, WCT), using variance component methods implemented in SOLAR. Results Genome‐wide scans for hemodynamic phenotypes identified quantitative trait loci (QTLs) with significant evidence of linkage on chromosomes 1 and 12 for WCT‐linked cardiac output (CO) (Logarithm of odds (LOD) score = 3.1) and systolic BP (LOD = 3.5), respectively. Suggestive evidence for linkage for WCT was found on chromosomes 3, 17 and 1 for heart rate (LOD = 2.3), diastolic BP (LOD = 2.4) and left ventricular ejection time (LVET), respectively, For reactivity (ΔWCT), suggestive QTLs were detected for CO on chr11 (LOD=2.5), for LVET on chr3 (LOD=2.0) and for End‐diastolic index on chr9 (LOD=2.1). Conclusion Mental stress revealed some of the largest number of significant and suggestive loci for normal BP reported to date. Some phenotypes with functional relationships shared the same chromosomal regions. The study of BP and its intermediate phenotypes under mental and physical stress may help reveal the genes involved in the pathogenesis essential hypertension