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Hypertension in a Leptin Intact Model of Metabolic Syndrome is Associated with Dyslipidemia but is Not a Consequence of Diabetes
Author(s) -
Johnson Jamie,
Tlem Hlawn kip,
Coy Kathy,
Peterson Richard G,
Packer C Subah
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1099.1
Subject(s) - dyslipidemia , hypertriglyceridemia , medicine , metabolic syndrome , diabetes mellitus , endocrinology , leptin , obesity , blood pressure , triglyceride , cholesterol
Hypertension is associated with diabetes and is a hallmark of metabolic syndrome (MetS). MetS is also characterized by obesity, dyslipidemia and diabetes. Existing MetS models have leptin defects not typical in MetS patients. A new rat model, ZDSD, develops increased body mass and type 2 diabetes in spite of having intact leptin. The objective of the current study was to determine if ZDSD develop hypertension. ZDSD systemic blood pressures, body weights, circulating lipids and glucose were monitored as functions of age and compared with control CD values. ZDSD and CD had similar growth curves but only ZDSD developed dyslipidemia followed by hyperglycemia. ZDSD developed high blood pressure by about 7 weeks of age but, interestingly, the hypertension was not a consequence of obesity or diabetes. However, dyslipidemia, especially hypertriglyceridemia, preceded development of hypertension. In conclusion, ZDSD do develop cardiovascular disease as is typical in MetS. Furthermore, results suggest that diabetes‐associated hypertension is likely causally related to dyslipidemia (hypercholesterolemia or hypertriglyceridemia) rather than to hyperglycemia in metabolic syndrome.