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Interstitial norepinephrine levels and local electrophysiological properties of the myocardium during sympathetic nerve activation
Author(s) -
Zhou Wei,
Vaseghi Marmar,
Ramirez Rafael,
Patel Sunny,
Shivkumar Kalyanam,
Mahajan Aman
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1098.1
Subject(s) - norepinephrine , stellate ganglion , medicine , ventricle , cardiology , stimulation , sympathetic nervous system , endocrinology , anesthesia , blood pressure , dopamine , pathology , alternative medicine
Cardiac sympathetic innervation originates mainly in the left and right stellate ganglia. The efferent and afferent fibers of the left stellate ganglion (LSG) predominantly innervate the left ventricle (LV), whereas the fibers of the right stellate ganglion (RSG) innervate the right ventricle. The major neurotransmitter, norepinephrine, shortens ventricular action potential duration (APD) and increases contractility. Activation recovery interval (ARI) can serve as a surrogate for APD in both animal models and patients. However, the linkage between myocardial interstitial norepinephrine levels and ARI during stimulation of left and right stellate ganglion remains unclear. In six anesthetized pigs, interstitial norepinephrine concentrations and ARIs were measured in the perfusion areas of the left anterior descending coronary artery. LV pressure and volume were recorded by a 5Fr Millar conductance catheter. LSG stimulation significantly shortened ARI (28%) and increased systemic blood pressure (SBP, 43%), LV dP/dtmax (200%), and interstitial norepinephrine (110%) with a mild change in heart rate (13%). RSG stimulation also significantly shortened ARI (100%) and increased SBP (63%), heart rate (80%), dP/dtmax (300%), and interstitial norepinephrine (120%). We conclude that both LSG and RSG play an important role in regulating LV function and local sympathetic nerve activity.