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Overfed Ossabaw swine demonstrate resistance to the harmful cardiovascular effects of metabolic syndrome
Author(s) -
Chu Louis M,
Lassaletta Antonio D,
Robich Michael P,
Laham Roger,
Liu Yuhong,
Burgess Thomas,
Sellke Frank W.
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1092.11
Subject(s) - medicine , endocrinology , metabolic syndrome , perfusion , dyslipidemia , contractility , ischemia , obesity , cardiology
Ossabaw swine fed a high‐fat diet develop metabolic syndrome. We investigated their utility as a model for chronic myocardial ischemia in the setting of metabolic syndrome. Chronic ischemia was induced in swine fed either normal chow (lean, n=9) or a high‐calorie diet (obese, n=9) by left circumflex artery ameroid placement. After 7 weeks, body weight, glucose tolerance, and serum lipids were measured. Measurements of cardiac hemodynamics, function, and perfusion were performed. Ischemic myocardium was harvested for molecular analysis. Obese swine demonstrated a 1.8‐fold greater percent‐increase in body weight (p=0.0003), 1.3‐fold increase in mean arterial pressure (p=0.02), 5.1‐fold greater fasting cholesterol (p<0.0001), and 2.1‐fold greater LDL:HDL ratio (p=0.0006). Fasting glucose values were similar between groups, but glucose values after dextrose challenge were 1.3‐fold greater in the obese group (p=0.04). However, myocardial perfusion, contractility, capillary density, and arteriolar density were similar between groups. Protein oxidation was reduced in the obese group, while expressions of PPAR‐alpha and PPAR‐gamma were 1.2‐fold and 1.3 fold greater than lean animals. Thus the cardiovascular system of Ossabaw swine is protected from the deleterious effects of hypertension, dyslipidemia, and glucose intolerance, perhaps via evolutionary upregulation of antioxidant PPAR pathways.