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Collateral Artery Development By Vasa Vasorum At The Site Of Femoral Artery Occlusion
Author(s) -
Yang Hsiao Tung,
Terjung Ronald L.,
Bowles Douglas K.,
Laughlin M. Harold
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1091.8
Subject(s) - vasa vasorum , collateral , femoral artery , medicine , cardiology , artery , occlusion , anatomy , collateral circulation , business , finance
Vasa Vasorum (VV), a microvessel network on the adventitial layer of large arteries, is recognized to play a role in vascular pathology. A network of collateral arteries develops in the pig with femoral artery (FA) occlusion. To study whether VV was associated with developing collateral vessels, healthy Yucatan pigs (35 to 40 kg) served as Controls (n=4) or received bilateral FA occlusion for 2 wk (n=4) or 8 wk (n=3). Hindquarter was perfused with gelatin‐bismuth solution following sacrifice. FAs were evaluated by Micro‐CT scan and histology. There were no tortuous vessels in the FA of Controls. Tortuous vessels arising from the proximal stump of the FA were 5.38±0.53 in two wks and 6.80±0.86 in 8 wks occlusion; numbers of collateral vessels inserted across the occlusion at 2 wks were 3.63±0.56, as compared to all the vessels at 8 wks (p<0.01). Some tortuous vessels appeared to arise from the VV in the micro‐CT images. Histochemical study showed enlarged VV budding from the proximal stump of the occluded FA. The stimuli for this vascular development are unclear; it may be related to pressure gradient, and other factors generated by occlusion of the FA. Our data show the involvement of the VV in collateral network development following occlusion of a large artery in a normal animal, whether the similar process could be found in patients with peripheral arterial disease is unknown. Supported by NIH P01HL 52490