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Cordyceps sinensis Cs‐4 restores aging‐associated changes in gene expression and extends lifespan in normal aged mice
Author(s) -
Tan NingZhi,
Barger Jamie L,
Zhang Yan,
Ferguson Scott B,
Wu ZiMei,
Prolla Tomas A,
Bartlett Mark,
Zhu JiaShi
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1090.13
Subject(s) - cordyceps , senescence , biology , medicine , endocrinology , physiology , traditional medicine
Cordyceps sinensis is believed to be an anti‐aging traditional Chinese herb. We previously reported that C. sinensis Cs‐4 (a mycelia fermentation product of C. sinensis ) improves glucose, lipid and energy metabolism and has antioxidant, anti‐fatigue and endurance effects. In this study we examined gene expression (GE) profiles of neocortex and gastrocnemius from young (5 months of age), old (25 mo) and old Cs‐4 treated (0.3 g/kg) C57Bl/6 mice. Age‐related changes in GE were clustered. Cs‐4 opposed GE of many changes that occurred with age (p<0.05). This anti‐aging effect was examined in a lifespan study in male & female ICR mice fed either control or Cs‐4 (0.5, 1.0 or 1.5 g/kg; n=48/group) beginning at 1 year of age. Calorie intake was adjusted twice a week to match the controls. No differences in body weight were noted among the groups. All control mice died before 3 years of age. The lifespan was extended 10–66 days at 50% survival with Cs‐4 and 45–153 days at 10% survival. The age of the oldest surviving mice was extended 152 days (1.5 g/kg) and >210 days (both 0.5 and 1.0 g/kg). Kaplan‐Meier analysis revealed the best extended lifespan and reduced the risk of death in mice receiving Cs‐4 0.5 g/kg (p=0.03). In conclusion, C. sinensis Cs‐4 reverses age‐related changes in GE and extends the lifespan of mice, supporting the traditional belief that C. sinensis Cs‐4 conveys anti‐aging benefits to humans.