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Effect of (−) epicatechin in the force of contraction of the heart in a model of cardiac hypertrophy in Wistar rat
Author(s) -
Zuñiga Carlos Alberto,
Miranda Iris Danae,
Guevara Gustavo,
Velez Juan,
Ceballos Guillermo Manuel,
Ocharan Maria Esther
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1085.15
Subject(s) - preload , afterload , cardiology , ventricle , contractility , medicine , muscle hypertrophy , volume overload , contraction (grammar) , frank–starling law of the heart , cardiac muscle , heart failure , hemodynamics , ejection fraction , stroke volume
Cardiac hypertrophy (HC) is an adaptive response that develops the myocyte, characterized by increasing its size to an increase of work that is exposed, modulated and/or modified by the presence of mechanical (volume overload) and hormonal (neurotransmission) stimuli The heart is the organ directly responsible for adequate perfusion. To carry out this function requires an appropriate shortening of myocardial fibers and their performance depends on three factors: preload (load or volume that distends the left ventricle before contraction or systole) afterload (resistance to ventricular ejection) and contractility (ability of the heart muscle to contract). In the present work to model HC hemodynamic overload, we can see that the fistula is still present three weeks after surgery and the results showed an increase in heart mass the ventricles walls and ventricular septum Wistar, a data reported by the literature as parameters of HC. On the other hand, in those Wistar rats had surgery for fistula and were treated with (−) ‐Epicatechin higher growth was observed in control rats and lower than in rats and untreated fistula, which indicates that flavonoid treatment prevents the formation of HC in this model, which due to the results obtained is feasible for the development of HC and drug testing.