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Post‐Exercise Heart Rate Recovery is Impaired in Anabolic Steroids Users
Author(s) -
Santos Marcelo Rodrigues,
Dias Rodrigo Gonçalves,
Laterza Mateus Camaroti,
Rondon Maria Urbana,
Moreau Regina Moraes,
Negrão Carlos Eduardo,
Alves Maria Janieire
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1084.6
Subject(s) - anabolism , heart rate , medicine , physical medicine and rehabilitation , cardiology , physical therapy , endocrinology , blood pressure
Purpose We hypothesized that heart rate recovery (HRR) would be lower in anabolic androgenic steroids users (AASU) compared with anabolic androgenic steroids nonusers (AASNU). Methods Eight AASU and 7 AASNU participated in the study. Anabolic steroid was tested by urine (chromatography‐mass spectrometry). Cardiopulmonary exercise was performed on treadmill ramp protocol. Heart rate was evaluated by a 12 leads EKG. Muscle sympathetic nerve activity (MSNA) was measured by microneurography. Results Peak oxygen consumption was lower in AASU compared with AASNU (45±2.27 vs. 52±1.85 ml/kg/min, P=.04). Peak HR was not different between groups (189±3 vs. 184±2 bpm, P=.28). There were no difference in peak respiratory exchange ratio between groups (1.26±.05 vs. 1.26±.03, P=.96). The HRR at first and second minute of recovery was lower in AASU than AASNU (18±2 vs. 26±1 bpm, P=.003; 34±4 vs. 43±1 bpm, P=.04, respectively). MSNA was higher in AASU than AASNU (29±3 vs. 20±1 bursts/min, P=.01). Further analysis showed an inverse correlation between MSNA and HRR (r=.64, P=.02). Conclusion The impairment in HRR during the post‐exercise period and the increased MSNA are consistent with autonomic dysfunction in AASU.