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Sex difference of endothelin B receptor‐dependent natriuresis in angiotensin II hypertension
Author(s) -
Kittikulsuth Wararat,
Pollock David M
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1079.9
Subject(s) - endocrinology , medicine , natriuresis , endothelin receptor , angiotensin ii , diuretic , excretion , renal function , diuresis , renin–angiotensin system , blood pressure , chemistry , receptor
Renal medullary endothelin B receptors (ET B ) facilitate sodium excretion and contribute to blood pressure (BP) regulation. Female rats have an attenuated hypertensive response to chronic angiotensin (Ang) II infusion compared to males. However, the underlying mechanism is not clear. Previously, we showed that ET B ‐dependent natriuresis is impaired in Ang II hypertensive male rats. In this study, we hypothesized that ET B function is preserved in Ang II hypertensive female rats. We compared the diuretic and natriuretic response to intramedullary infusion of ET B agonist sarafotoxin 6c (S6c) in female rats treated with Ang II (260 ng/kg/min s.c.) or vehicle for 14 days. Urine was collected during 2 consecutive 20‐min periods for baseline collection followed by 4 additional 20‐min periods of intramedullary saline or S6c (0.45 μg/kg/h) infusion. S6c increased urine flow (UV; Δ7.5±2.3 μl/min, p<0.05) and sodium excretion (UNaV; Δ1.1±0.2 μmol/min, p<0.05) in the vehicle group. In contrast to males, female Ang II hypertensive rats had increased UV (Δ8.3±2.4 μl/min; p<0.05) and UNaV (Δ1.1±0.3 μmol/min, p<0.05) during intramedullary S6c infusion. S6c did not affect BP or medullary blood flow in either group of female rats. These data show that renal medullary ET B function is preserved in female rats during chronic Ang II infusion, suggesting that ET B function could serve to limit hypertension in females compared to males.