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The impact of cisplatin induced renal failure on baroreflex regulation of renal sympathetic nerve activity (RSNA) in the male Wistar rat
Author(s) -
Goulding Niamh Elisha,
Johns Edward J
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1078.13
Subject(s) - baroreflex , medicine , baroreceptor , blood pressure , reflex , anesthesia , cardiology , endocrinology , heart rate
Renal failure (RF) in man is associated with sympatho‐excitation. We investigated whether low and high pressure baroreceptor regulation of RSNA was deranged in a cisplatin‐induced rat RF model. Rats received 5mg/kg cisplatin i.p. 7 days prior to study. Following anaesthesia (i.p. chloralose/urethane) baroreflex gain curves for RSNA were generated using a four parameter logistic regression equation and analysed for the level of impairment of RSNA. Control rats ( n =8) had blood pressure (BP) of 100±1 mmHg and displayed a baroreflex RSNA curve with a sensitivity (slope, A2) of 0.16±0.01%/mmHg. RF rats ( n =8) had BP of 96±1 mmHg and exhibited a significantly (P<0.05, Students unpaired t‐test) blunted baroreflex curve with a sensitivity of 0.08±0.04 %/mmHg. During an acute volume expansion (i.v. saline 0.25% body weight/min for 30min) to challenge low‐pressure barorecptors, control rats exhibited a reflex decrease in RSNA of some 70±6%, whereas it was unchanged in the RF group (3±2%). These data reveal a dys‐regulation of both the low and high pressure baroreflex control of RSNA which could contribute to the hypertension associated with RF in man. Funding was from Health Research Board, Ireland.