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Caloric restriction and exercise training alter reciprocal 24‐hour profiles of PYY and ghrelin in normal weight premenopausal women
Author(s) -
Hill Brenna Renee,
De Souza Mary Jane,
Sato Rino,
Williams Nancy I
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1070.5
Subject(s) - ghrelin , medicine , endocrinology , growth hormone receptor , weight loss , meal , body weight , hormone , chemistry , growth hormone , obesity
We previously reported that Ghrelin (Ghr) and PYY exhibit diurnal rhythms driven by meal timing and energy content. PYY opposes the actions of Ghr at the hypothalamus and thus, we hypothesized circulating PYY and Ghr would be inversely correlated over 24hr but that after weight loss this relationship would change to reflect a hormonal milieu that would facilitate the regaining of body weight. Seven subjects were studied before and after a 3‐mos intervention consisting of controlled feeding (1800±232 kcals reduced by 453±413 kcals) and supervised aerobic exercise (5 d/wk, 59±22 min/bout). Blood samples were obtained q10 min for 24h and assayed for total PYY and total Ghr. Calculated variables included 24hr area under the curve (AUC) and post meal rises/declines (MR/MD). Body weight (−2.8±2.6kg) decreased from pre to post (p<0.05) while VO2max increased (8.31±2.1ml/kg/min, p=0.01). At baseline, 24h profiles of Ghr and PYY were inversely correlated (r=−0.31, p=0.04) with MD in Ghr matching MR in PYY: breakfast (r=−0.80) and lunch (r=−0.85) (p<0.05). After weight loss, Ghr AUC increased (p=0.03) but not PYY AUC, and Ghr and PYY were no longer correlated across 24 hr. Ghr and PYY are inversely related when body weight is stable, but are “uncoupled” after weight loss which may reflect a hormonal milieu that promotes weight regain. Funded by NIH Grants: 1R01HD39245‐01A1 and M01 RR 10732