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A Low‐Fat Dairy Product Enriched with Plant Sterols Improves LDL Cholesterol in Both Normal and Overweight Moderately Hypercholesterolemic Subjects
Author(s) -
Byambaa Enkhmaa,
Perrin Catherine,
Gagneau Murielle,
Deckelbaum Richard J,
Berglund Lars
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.107.7
Subject(s) - plant sterols , overweight , food science , ldl cholesterol , cholesterol , chemistry , obesity , medicine , sterol , biochemistry
Objective To assess plasma lipids across insulin resistance and obesity status in subjects consuming a single plant sterol (PS)‐enriched low‐fat dairy product for 6 weeks. Design A randomized, double‐blind, placebo‐controlled, multi‐center study in 168 (107 overweight/44 obese) subjects, divided into 2 groups (control and PS‐enriched). The PS‐enriched product contained 1.6 g PS per 80 mL serving. Results Plasma LDL‐C was lower in the PS‐enriched vs. control group (−5.9 ± 1.6%, P<0.001). Changes in TC paralleled those in LDL‐C with significant differences between the two groups. Plasma HDL‐C, triacylglycerol, apoB, apoA‐I and apoB/apoA‐I ratio did not change, and no serious adverse events related to the product were reported. Among subjects in the 3 rd insulin tertile, the PS‐enriched product lowered LDL‐C by −9.0 ± 2.7% vs. control group (P<0.01). Also in overweight subjects (n=107), LDL‐C was lowered in the PS‐enriched vs. control group (−7.3 ± 2.0%, P<0.001). Conclusion A single supplementation of 1.6 g PS‐enriched low‐fat dairy product significantly lowered TC and LDL‐C. LDL‐C levels were significantly lower in the PS group among overweight subjects as well as among subjects with increased insulin resistance, suggesting that this product might be a valuable tool in subjects at increased risk for cardiovascular disease. Research Support: This study was funded by Danone Research, France.