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Changes of leptin, but not ghrelin or n‐6/n‐3 polyunsaturates, correlate with improvements in insulin resistance in obese adults following weight loss
Author(s) -
Huang MengChuan,
Su YiRu,
Wang TsuNai
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.107.3
Subject(s) - leptin , medicine , insulin resistance , ghrelin , endocrinology , weight loss , insulin , obesity , diabetes mellitus , hormone
Obesity may lead to insulin resistance, type 2 diabetes, and coronary heart diseases. Leptin, ghrelin, and polyunsaturates play different roles in insulin sensitivity. We assessed the impact of weight loss on insulin resistance, serum leptin/ghrelin, and erythrocyte n‐6/n‐3 polyunsaturate profile. The intervention group constituted twenty‐eight obese adults participating in a dietitian‐led weight loss program, and the control lean individuals (n=14) were recruited from the community. The intervention subjects had a mean weight loss of 5.7±3.9 kg followed by a 19.7% and 22.5% reduction in HOMA‐IR and leptin, and an 11.75% increase in ghrelin (all p<0.05). Erythrocyte n‐6 and n‐3 polyunsaturates increased by 3.0% and 17.2% (all p<0.05). Leptin changes, but not ghrelin or n‐6/n‐3 polyunsaturates, significantly differed (p<0.05) in those with improved insulin resistance after weight loss (changes of HOMA‐IR<0) than those with no improvement (changes of HOMA‐IR≥). After adjusting for weight change, increased leptin independently correlated with increased risk of no improvement in HOMA‐IR (OR=1.80, p=0.04). In conclusion, participants following weight loss had improvements in insulin resistance and several metabolic parameters. Insulin resistance improvement may have been partially mediated by leptin.