Premium
Adipose‐Derived Stem Cells Ameliorate STZ‐Induced Pancreatic β Cell Damage in Type 1 Diabetes
Author(s) -
Li Yueying,
Liu Hanhan,
Li Yinping
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1063.8
Subject(s) - adipose tissue , medicine , mesenchymal stem cell , stem cell , pancreas , type 1 diabetes , diabetes mellitus , endocrinology , insulin , pathology , biology , genetics
Mesenchymal stem cells have been indicated to be prospective tools in the treatment of autoimmune diseases such as arthritis, experimental autoimmune encephalomyelitis, etc. Here, we intend to investigate the possible effect of adipose‐derived mesenchymal stem cells (ADSC) on type 1 diabetes. ADSC were cultured from the adipotic tissue of abdomen in Sprague ‐Dawley rats. 100 mg/kg.d streptozocin was injected into Balb/c mice for 5 consecutive days to establish the model of type 1 diabetes. ADSC were then injected into mice intravenously once a week for 8 weeks. Blood glucose was examined once a week and the mice were killed eight weeks later, serum and pancreases were collected. Our results showed that the levels of blood glucose decreased gradually after injection of ADSC compared to that of the models without injection of ADSC. In parallel, serum levels of insulin were increased. Moreover, ADSC effectively suppressed β‐cell damage and inhibited infiltration of inflammatory cells in the pancreas. In conclusion, we proposed that ADSC can protect pancreatic β‐cell from inflammtory destruction and maintain blood glucose levels in type 1 diabetes. The work is supported by National Natural Science Foundation of China (30800428) and Doctoral Fund of Ministry of Education of China (20070486086)