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Exercise induced plasma glucose adjustments during exercise is dependent on adrenomedullary secretion
Author(s) -
Coimbra Candido Celso,
Rodrigues Alex Guazzi,
Lima Nilo Resende,
Marubayashi Umeko
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1058.3
Subject(s) - medicine , endocrinology , chemistry , saline , secretion
To investigate the influence of medullary adrenal secretion on plasma glucose regulation during exercise, Phy (Eserine 5x10‐6M) was injected into the lateral ventricle of normal (INT) or bilaterally adrenodemedullated (ADM) untrained rats. Plasma glucose, lactate and free fatty acids were measured in the rats while they were exercising on a treadmill (20 m.min‐1, 5% inclination) until fatigue after drug injection. In resting rats, Phy increased plasma glucose only in INT animals without any effect on plasma lactate and free fatty acids (FFA). Icv injection of Phy in INT rats immediately prior to exercise markedly increase plasma glucose concentration that remained higher during all running time compared to INT saline injected rats (10.7±0.2 mM, Phy, n=7, vs 8.5±0.1 mM, n=8, p<0.05). Phy treatment did not affect the exercise‐induced increase in plasma lactate and FFA concentrations. In contrast, adrenodemedullation abolished the hyperglycemic effect of Phy treatment in resting as well as in exercising rats without affect the exercise induce‐increase in plasma lactate and FFA concentration. In conclusion, the exercise‐induced plasma glucose adjustment during exercise involving central cholinergic activation is dependent on adrenodemedullary secretion in rats. Furthermore, the exercise induced increase in plasma lactate and FFA concentration occurs independent of sympathoadrenal system activation.