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Voluntary exercise, spontaneous physical activity, and food consumption in High Runner lines of mice
Author(s) -
Copes Lynn Erin,
Schutz Heidi,
Dlugsoz Elizabeth M,
Acosta Wendy,
Chappell Mark A.,
Garland Theodore
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1057.20
Subject(s) - zoology , wheel running , food consumption , turnover , physical activity , medicine , physical therapy , biology , economics , management , agricultural economics
To explore the effect voluntary exercise has on spontaneous physical activity (SPA, aka non‐exercise activity thermogenesis), we housed 50 female mice from lines that had been artificially selected for high endurance running (HR lines) and 50 mice from non‐selected control (C) lines in cages with or without wheels. Wheels were monitored each 1‐min interval. All 100 cages had passive infrared sensors to monitor SPA during each 1‐min interval. Data presented here are from week 8 of the 12‐week experiment, at which point the mice had plateaued in body mass and weekly wheel‐running distance. The total SPA of both HR and C mice was reduced (9.9 to 8.2 h and 8.5 to 7.6 h, respectively) when they had wheel access, and the reduction was a function of both duration and average intensity of SPA. However, total duration of activity (SPA + running) was still 1/3 greater when mice were housed with wheels, and food consumption was increased. Thus, wheel running was not fully compensated by the reduction in SPA. Both duration and intensity of wheel running and SPA were positive, significant predictors of food consumption. Wheel‐running duration has a stronger effect than the average running speed, while for SPA, the intensity of activity has a stronger effect. To our knowledge, this sort of detailed analysis of the effects of different aspects of activity on food consumption has not previously been reported for a non‐human animal. Funding by NSF DDIG #0925793 to LC and IOB‐0543429 to TG. Grant Funding Source : NSF