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The effects of regular endurance exercise on IL‐6 and the sympathetic nervous system
Author(s) -
Komine Hidehiko,
Yoshizawa Mutsuko,
Maeda Seiji,
Shimojo Nobutake,
Takai Yohei,
Akazawa Nobuhiko,
Yokoi Takashi
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1056.5
Subject(s) - sympathetic nervous system , medicine , endurance training , nervous system , neuroscience , physical medicine and rehabilitation , physical therapy , psychology , blood pressure , psychiatry
Several studies have reported that regular endurance exercise attenuated the circulating IL‐6 concentration, but the underlying mechanism remained uncertain. We tested the hypothesis that the exercise‐induced alteration of IL‐6 would be associated with the sympathetic nervous system. Subjects were 17 young men trained in endurance exercise and 15 age‐matched sedentary men. Blood sample was obtained from the brachial vein, and serum IL‐6 concentration was measured by ELISA. Plasma adrenaline and noradrenaline concentration were measured as an index of sympathetic nerve activity. IL‐6 was lower in the exercise‐trained, than in the sedentary group (P<0.05). IL‐6 was correlated with adrenaline in the trained group (r=0.63, P<0.05), but such correlation was not observed in the sedentary group. These results suggest that regular endurance exercise attenuates IL‐6, which may be partly associated with sympathetic adrenergic mechanism.