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Resistance training prevents hypertension and improves cardiac autonomic modulation in alloxan diabetic rats
Author(s) -
Barreto André Sales,
Mota Marcelo Mendonça,
Fontes Milene Tavares,
ResendeNeto José Melquiades,
SantanaFilho Valter Joviniano,
BarretoFilho José Augusto,
Santos Márcio Roberto V
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1056.13
Subject(s) - baroreflex , medicine , blood pressure , cardiology , heart rate , heart rate variability , balance (ability) , glycemic , autonomic nervous system , qt interval , anesthesia , endocrinology , physical therapy , insulin
The aim of this study was to evaluate the effects of resistance training on blood pressure, ventricular repolarization, baroreflex sensitivity and cardiac autonomic balance in diabetic rats. The resistance training consisted of 3 sets of 10 repetitions performed at 40% of one repetition maximum test, 3 days/wk over 8 wks in squat‐training apparatus. Baroreflex sensitivity was analyzed by sequence method and cardiac autonomic balance by heart rate variability in the frequency domain. Diabetes increased glycemia (from 83 ± 8 to 381 ± 41 mg/dl, p<0.05), mean blood pressure (from 104.7 ± 5.4 to 125.1 ± 5.4 mmHg, p<0.05), QTc interval (from 4.4 ± 0.1 to 5.1 ± 0.1 ms, p<0.05), reduced baroreflex sensitivity (from 2.01 ± 0.3 to 0.38 ± 0.1 ms/mmHg, p<0.05) and impaired the cardiac autonomic balance. Resistance training was able to produce reduction on the glycemia (270 ± 17 mg/dl, p<0.05), prevented the increase of mean blood pressure (108 ± 3 mmHg, p<0.001) and QTc interval (4.6 ± 0.1 ms, p<0.01), the reduction of baroreflex sensitivity (2.63 ± 0.5 ms/mmHg, p<0.01) and disturbance on the cardiac autonomic balance. These results suggest that resistance training promotes a better glycemic control, prevents hypertension and improves baroreflex sensitivity and cardiac autonomic balance in diabetic rats.