Premium
Fever blunts and overheating enhances arousal from sleep during intermittent hypoxia in infant rats
Author(s) -
Schneider Robert,
Tobia Christine,
Darnall Robert
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1053.23
Subject(s) - habituation , arousal , hypoxia (environmental) , overheating (electricity) , medicine , sudden infant death syndrome , anesthesia , heart rate , psychology , blood pressure , audiology , chemistry , oxygen , pediatrics , neuroscience , physics , organic chemistry , quantum mechanics
Increased body temperature (Tb) and impaired arousal mechanisms have been implicated in The Sudden Infant Death Syndrome (SIDS). Since the thermoregulatory mechanisms involved in overheating and fever are different, we postulated that external heating and fever would have different effects on arousal in response to hypoxia. In a previously described model of arousal and arousal habituation in response to intermittent hypoxia, we evaluated arousal in response to four 3‐min exposures to 10% oxygen in P15 rat pups after external overheating (Tb=38.2 ± 0.1 o C), fever (IL‐1B) (Tb=37.8 ± 0.1 o C) and control conditions (Tb=35.9 ± 0.1 o C). Febrile pups had longer time to arousal (latencies) (P=0.024) and overheated pups had shorter latencies (P=0.009) than controls. Also, latency progressively increased with successive hypoxia exposures (habituation) in the febrile and control pups, but not in the overheated animals (P<0.001). Changes in chamber [O 2 ] and oxyhemoglobin saturation mirrored the changes in latency. Baseline heart rate (HR) tended to be higher in the febrile and overheated animals compared to controls and HR increased during hypoxia in the febrile and control pups but not in the overheated animals (P=0.001). These data suggest that although both overheating and fever elevate Tb, only fever blunts arousal in response to intermittent hypoxia. NIH PO1 HD36379.