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Effect of Nandrolone Decanoate Treatment on Contractile Responses of Male Rats Skeletal Muscles
Author(s) -
Ramadan Wiam,
Joumaa Wissam H.
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1051.50
Subject(s) - endocrinology , medicine , chemistry , contracture , soleus muscle , nandrolone , anabolism , contraction (grammar) , adult male , skeletal muscle , surgery
This study examine if the administration of different doses of an anabolic‐androgenic steroids, nandrolone decanoate (ND), could produce changes in contractile responses of untrained rat fast‐ ( edl ) and slow‐ ( soleus ) twitch skeletal muscles. Male adult rats received weekly an intramuscular injection of sterile peanut oil (control; C), 0.75 mg/kg (Therapeutical‐dose; TD), 1.5 mg/kg (low‐dose; LD), 6 mg/kg (Intermediate‐dose; ID) or 15 mg/kg (High‐dose; HD) of ND during 8 weeks. Compared with respective C, although no significant effect was observed in slow and fast‐ twitch characteristics for TD, LD and ID rats, an increasing by 103% in the amplitude of fast‐ twitch of HD animals and no significant effect was observed in the time constant of relaxation. A prolongation in the time constant of relaxation was observed in slow‐ twitch fibers of HD rats and no significant modification was observed at the level of amplitude of contraction generated. Moreover, no significant effect was observed in K‐contracture characteristics of slow‐ muscles of TD, LD, ID and HD rats, a progressive increase in the amplitude of K‐contracture was observed in ID (17%) and HD (57%) of ND treated rats and no significant modification was observed in the kinetic of the contracture. These results suggest that the effect of ND treatment of male rats is muscle types and dose dependent and the edl muscles are more sensitive than soleus muscles to treatment.