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Functional morphology of the renal inner medulla of the desert rodent Dipodomys merriami
Author(s) -
Issaian Tadeh,
Urity Vinoo B,
Braun Eldon J,
Dantzler William H,
Pannabecker Thomas L
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1047.6
Subject(s) - medulla , renal medulla , anatomy , kidney , nephron , rodent , biology , chemistry , medullary cavity , endocrinology , ecology
We hypothesize that the architecture and tubular transport necessary for production of highly concentrated urine is accentuated in the inner medulla of Dipodomys merriami . Three‐dimensional architecture of nephron and vascular segments in the renal inner medulla (IM) was assessed with digital reconstructions from physical tissue sections. Tubules and vessels were identified by indirect immunofluorescence using antibodies and lectins that recognize segment‐specific proteins. CDs form the central organizing motif in the IM. Medullary loop of Henle segmentation resembles that of other rodents as judged with electron microscopy. CDs, AVR, and ATLs, when viewed in transverse sections, form interstitial nodal spaces, raising the possibility that lateral solute diffusion from ATLs and CDs into AVR is preferentially restricted to these spaces. Functional morphology of the Dipodomys kidney and the Munich Wistar kidney suggests two key differences. The water channel AQP1 is expressed along a greater percentage of the DTL in Dipodomys , suggesting that a longer length of DTL water permeability may be key to its increased urine concentrating ability. Additionally, a smaller percentage of the prebend segment from Dipodomys expresses the Cl channel, ClC‐K1, suggesting reabsorption of NaCl along a narrower axial segment may contribute to its increased urine concentrating ability.