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Modeling the CPG‐based Control of Cat Hindlimb Movement During Locomotion
Author(s) -
Markin Sergey N,
Klishko Alexander N,
Shevtsova Natalia A,
Lemay Michel A,
Prilutsky Boris I,
McCrea David A,
Rybak Ilya A
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1046.1
Subject(s) - central pattern generator , hindlimb , biceps , lamprey , cpg site , anatomy , neuroscience , gait , trunk , motor control , biology , medicine , physical medicine and rehabilitation , ecology , biochemistry , gene expression , fishery , rhythm , gene , dna methylation
A computational neuro‐biomechanical model of cat locomotion with two hindlimbs controlled by a loconotor spinal central pattern generator (CPG) has been developed. The 2D biomechanical model includes two three‐joint hindlimbs and the trunk. Each hindlimb consists of three rigid segments connected by hinge joints and is actuated by nine muscles including two bifunctional muscles: biceps femoris posterior (BFP) and rectus femoris (RF). The architecture of spinal circuits and the locomotor CPG is based on the model of the two‐level locomotor CPG (Rybak et al. 2006) consisting of the flexor and extensor half‐centers and pattern formation (PF) circuits. The model of PF circuits was extended to incorporate additional interneuron populations controlling the activity of BFP and RF. The extended model of spinal circuits and the CPG allow generation of the full repertoire of muscular activity patterns including firing patterns of BFP and RF observed during fictive and normal locomotion, which are subject to afferent control of the CPG and depend on gait. The model demonstrates stable locomotion and exhibits realistic patterns of muscle activation, limb kinematics, and ground force dynamics. The model was used for investigation of the role of afferent control of the CPG for stable locomotion. Supported by NIH: R01NS048844 and R01 EB012855.