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Renoprotective effect of Alpiniae oxyphyllae Fructus on ischemia/reperfusion‐induced acute renal failure in rats
Author(s) -
Kim Eun Ju,
Ahn You Mee,
Xu Lan,
Kang Dae Gill,
Lee Ho Sub
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1041.41
Subject(s) - renal ischemia , ischemia , endocrinology , kidney , medicine , fractional excretion of sodium , renal sodium reabsorption , reabsorption , renal function , creatinine , urinary system , pharmacology , chemistry , reperfusion injury
The present study was designed to examine whether water extract of Alpiniae oxyphyllae Fructus (AAO) has an effect on renal functional parameters in association with the expression of water channels (AQP‐2, 3) and sodium potassium pump (Na,K‐ATPase [alpha]1 subunit) in rats with the ischemia/reperfusion‐induced acute renal failure (ARF). Polyuria caused by down‐regulation of renal AQP‐2, 3 in the ischemia/reperfusion‐induced ARF rats was markedly restored by administration of AAO (200 mg/kg/day p.o.) with restoring expression of AQP‐2, 3 in the kidney. The expression of Na,K‐ATPase ¥á1 subunit was also restored in the ischemia/reperfusion‐induced ARF rat by administration of AAO. The renal functional parameters including creatinine clearance (Ccr), urinary sodium excretion, urinary osmolality, and solute‐free reabsorption were also markedly restored in ischemia‐ARF rats by administration of AAO. Periodic acid Schiff (PAS) staining showed that administration of AAO improved tubular damage I/R‐induced ARF. Taken together, the present study suggested that administration of AAO ameliorates the urine concentration and renal functions in rats with ischemia/reperfusion‐induced ARF, through the restoring of AQP‐2, 3 and Na,K‐ATPase.