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Ghrelin receptor and heart hemodynamic in obese adult mice overfed during lactation
Author(s) -
Moura Aníbal Sanches,
Miranda Glauciane Lacerda,
Vieira Anatália Kutianski Gonzales,
Bernardo Amélia Faustino,
Melo Soares Vivian,
Lessa Juliana Gomes,
Cortez Erika Costa,
Souza RodriguesCunha Alessandra Cordeiro,
Mattos Ana Marcondez,
GarciaSouza Érica Patricia,
Sichieri Rosely
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1029.4
Subject(s) - medicine , endocrinology , heart failure , hemodynamics , ventricle , lactation , ghrelin , protein kinase b , phosphorylation , chemistry , receptor , biology , pregnancy , genetics , biochemistry
Obesity is related to myocardial dysfunction and heart failure. We examined key proteins of cardiomyocyte metabolism in heart left ventricle from obese (OG) and control (CG) groups from adult mice (180 days) overfed during lactation. Hearts from both groups were also analyzed by the Langendorff System during Baseline (CGBL, OGBL) and Ischemia/Reperfusion (CGIR, OGIR) conditions. OG showed a significant increase in total body fat with a larger adipocytes area (p <0.0001). Heart mass and heart mass/body mass (p<0.0001) were also increased with increased cardiomyocytes area (p<0.001). Ghrelin receptor (GHS‐R1a) content (p<0.02) and AKT expression and phosphorylation (p<0.03) was increased in the heart of OG. Hemodynamic showed higher EDP and Tau (relaxation time) in OGIR compared to BL (p<0.05); Max dp/dt lower in IR compared to BL (p<0.05); Min dp/dt lower in the CGIR and OGIR compared to OGBL (p<0.05). We conclude that overnutrition during lactation leads to obesity in adulthood, with myocardial remodeling, GHS‐R1a and AKT phosphorylation content increasing associated to hemodynamic changes in the heart. Supported by CNPq (305903/2007); FAPERJ (E‐26/110.578/2009).