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Hemodynamics and cardiac function in adults with increasing metabolic risk
Author(s) -
Edgell Heather,
Hodges Gary,
Fleischhauer Arlene,
Petrella Robert,
Shoemaker J. Kevin
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1028.1
Subject(s) - hemodynamics , medicine , ejection fraction , cardiology , ventricle , cardiac function curve , cardiac output , blood pressure , waist , heart failure , obesity
Risk for cardiovascular disease is higher in people with a greater number of metabolic abnormalities yet little information exists regarding hemodynamics associated with metabolic risk accumulation. This study investigated hemodynamics (cardiac output (Q), total peripheral resistance (TPR)), and cardiac function (echocardiography; left ventricle thickness (LVT), ejection fraction (EF), pre‐ejection period (PEP)) in people with 1 (n=8–9), 2 (n=20–22), 3 (n=17–19), or 4 (n=6) metabolic risk factors (RF) (high blood pressure, cholesterol, blood glucose, waist circumference). Based on linear regression, increasing risk was associated with higher Q (1RF:3.5±0.2; 4RF:5.5±0.5L/min/m2 P=0.02), lower TPR (1RF:27.3±2.6; 4RF:16.4±1.7mmHg/L/min/m2; P=0.09), normal EF (1RF:66.1±2.5; 4RF:69.8±4.2mL; P=0.50) and LVT (1RF:0.94±0.03; 4RF:0.96±0.03cm; P=0.84) but shorter PEP (1RF:67.5±2.4; 4RF:50.1±5.0ms; P=0.03). These data indicate a change in cardiac systolic function with greater metabolic risk. Furthermore, in opposition to common hypotheses, there was little evidence indicating detrimental effects of increasing metabolic risk on hemodynamics. (Funded by Canadian Institutes of Health Research)