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Association between Central Artery Stiffness and Cerebral Perfusion in Deep Subcortical White Matter
Author(s) -
Tarumi Takashi,
Shah Furqan,
Tanaka Hirofumi,
Haley Andreana
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1024.4
Subject(s) - pulse wave velocity , medicine , arterial stiffness , cardiology , pulse pressure , cerebral perfusion pressure , cerebral blood flow , perfusion , white matter , blood pressure , magnetic resonance imaging , radiology
Background Central arterial stiffness is a strong independent risk factor for cerebrovascular disease. Animal study demonstrated that higher pulse pressure in cerebral artery is associated with hypertrophic remodeling of the microvasculature, leading to increased vascular resistance to the blood flow. Cerebral hypoperfusion is considered the primary cause of cerebrovascular disease including stroke, vascular dementia, and Alzheimer's disease. The aim of this study was to determine whether central arterial stiffness is associated with cerebral perfusion in human. Methods A total of 35 middle‐aged adults (15 men and 20 women; 49±7 yrs) were studied. Central aortic stiffness was determined by carotid‐femoral pulse wave velocity. With quantitative perfusion image technique using functional MRI, regional cerebral perfusion in deep subcortical white and gray matter was measured. Results Carotid pulse pressure and carotid‐femoral pulse wave velocity were significantly associated with the perfusion in the frontal white matter (r = −0.36 and −0.61 respectively, P<0.05). Hierarchical linear regression analysis revealed that carotid‐femoral pulse wave velocity significantly explains 22 % of variability in the frontal white matter perfusion (β = −0.67, P<0.05), independently from age and blood pressure. Conclusions Central aortic stiffness is strongly associated with the cerebral perfusion in frontal white matter even after the adjustment for age and blood pressure.