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Prostanoids mediate functional hyperaemia in healthy young and older men in an oxygen‐dependent manner
Author(s) -
Davies Christopher Steven,
Townend Jonathan N,
Marshall Janice M
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1023.6
Subject(s) - hyperaemia , medicine , vasodilation , hyperoxia , forearm , anesthesia , plethysmograph , venous blood , blood flow , cardiology , endocrinology , surgery , lung
We have previously shown in young subjects that the hyperaemia following static exercise is reduced by both hyperoxia and cyclooxygenase inhibition with aspirin. We therefore hypothesised that functional hyperaemia is at least partly mediated by vasodilator prostanoids in an oxygen (O2) dependent manner. In the present study, 12 young (18–24) and 12 older (50–70) healthy, recreationally active male subjects performed static and rhythmic handgrip exercise at 50% of their maximum force for 2 minutes, separated by 30 minutes rest. Experiments were performed on 4 separate days in random order: following either 600mg soluble aspirin in orange squash or placebo, and with either room air or 40%O2 breathed through a face mask during the period of exercise. Forearm blood flow was measured using venous occlusion plethysmography and arterial pressure was recorded by finapress. Venous blood samples were taken from the exercising arm for analysis of venous prostaglandins. Administration of interventions (O2, aspirin and both combined) in young subjects caused a reduction in functional hyperaemia relative to control, whereas in older subjects the interventions caused the hyperaemia to increase. Thus prostanoids are released during exercise in an O2‐dependent manner and production potentially shifts from vasodilator to vasoconstrictor prostanoids with ageing. Research was funded by the British Heart Foundation.