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The Accuracy of Intraoperative Frozen‐Section Diagnosis in Clinical Staging of Endometrial Carcinomas According to the AJCC 7th Edition Guidelines
Author(s) -
ZULFIQAR MUHAMMAD IMRAN,
AHMED YASIN,
SHAHAB ASIF,
TASHJIAN RANDY,
MAZZARA PAUL
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1002.22
Subject(s) - frozen section procedure , medicine , stage (stratigraphy) , hysterectomy , endometrial cancer , radiology , cancer staging , surgery , cancer , paleontology , biology
Endometrial carcinoma is the most common invasive cancer of the female genital tract accounting for 6% of all invasive cancers in women. The prognosis and surgical staging depends on the histologic grade, depth of myometrial invasion and cervical involvement. Surgical staging consists of total abdominal hysterectomy, bilateral salpingo‐oophorectomy, peritoneal cytology, and pelvic lymphadenectomy. Intraoperative frozen section analysis followed by formalin fixed permanent section analysis is used for surgical staging. We compared the accuracy of frozen section staging with the accuracy of permanent section staging. Methods A retrospective analysis was performed on 46 consecutive patients with endometrial carcinoma between February 2005 and June 2010 at St. John Hospital and Medical Center in Detroit, Michigan. Frozen section staging was performed on all the cases followed by permanent section staging using the AJCC 7 th edition staging manual. Results Comparison between frozen section and permanent section examination did not show a significant difference in the depth of myometrial invasion (p = 0.7). A greater difference was observed with respect to cervical involvement, but this finding was not statistically significant (p = 0.2). Conclusion Although sampling of the specimen at frozen section has its limitations, the stage rendered through intraoperative examination generally correlates well with the pathologic stage reported upon permanent section examination.