Premium
PROTEOME DYNAMICS ASSOCIATED TO THE PATHOBIOLOGY OF ALZHEIMER'S DISEASE
Author(s) -
De Jesús Héctor José
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.lb88
Subject(s) - neurodegeneration , progressive supranuclear palsy , corticobasal degeneration , frontotemporal dementia , neuroscience , tauopathy , proteome , biology , disease , parkinsonism , dementia , medicine , bioinformatics , pathology
The central role of the microtubule associated protein tau in neurodegeneration is underscored by the identification of mutations on the tau gene in patients with frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP‐17), corticobasal degeneration (CBD), and progressive supranuclear palsy (PSP), as well as been considered as a pathological hallmark in Alzheimer's disease. Several hypotheses have been proposed to explain the pathobiological mechanisms induced in neurodegenerative diseases associated to tau pathology, collectively known as tauopathies. However, the molecular mechanisms underlying tau‐mediated neurodegeneration are poorly understood. The main goal of our studies is to identify and characterize proteome changes underlying tau‐mediated neurodegeneration. Proteome dynamics could be defined as transient changes in post‐translational modification, interactions, function and/or subcellular localization. Taking this concept as a research approach has led us to the identification of protein level changes associated to tau‐mediated neurodegeneration. The identification of affected proteins may provide insights on the pathobiological process linked to tau‐mediated neurodegeneration. The approach, result and significance of the findings will be discussed.