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Alcohol consumption promotes insulin resistance via accumulation of proinflammatory responses in the NIDDM murine model
Author(s) -
Matsumoto Hiroshi,
Tanaka Maki,
Tadeda Kenji,
Ishizaka Atsushi,
Okazaki Shunichiro,
Katada Ryuichi,
Mizuo Keisuke,
Watanabe Satoshi
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.lb655
Subject(s) - insulin resistance , proinflammatory cytokine , endocrinology , medicine , insulin , fatty liver , diabetes mellitus , type 2 diabetes , inflammation , disease
Alcohol consumption causes fatty liver disease and other organ damages. On the other hand, alcohol consumption is one factor of development of metabolic syndrome. We hypothesized alcoholic fatty liver disease disturbs glucogenesis, resulting in insulin resistance. The Nagoya‐Shibata‐Yasuda (NSY) mouse is an animal model of human Type II (non‐insulin‐dependent) diabetes mellitus (NIDDM) where the onset is age‐dependent, the animals are not severely obese, and both insulin resistance and impaired insulin response to glucose contribute to disease development. In the present study, we clarified the effect of ethanol consumption on the onset age and the pathogenesis of diabetes and to analyze glucogenesis and proinflammatory response in the NSY mice. We used the NSY mice and control C3H/He mice fed Lieber‐DeCarli diet (5% v/v ethanol) for 4 weeks. Insulin resistance was evaluated in overnight‐fasted mice by insulin tolerance ant glucose tolerance tests. Alcohol diet promoted insulin resistance significantly compared as control liquid diet. Insulin resistance in the NSY mice occurred significantly earlier than the C3H/He mice fed alcohol diet. Expression of TNFalpha, IL‐1beta, IL‐6, and other proinflammatory response genes in the liver of the NSY mice were significantly higher than the control mice fed alcohol diet. On the other hand, PGC‐1alpha related to gluconeogensis was deceased by alcohol diet. In conclusion, alcohol consumption induces accumulation of proinflammatory responses in the liver to promote insulin tolerance.