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Nitric oxide and renal haemodynamics during postnatal maturation: Role of angiotensin receptors
Author(s) -
Vinturache Angela Elena,
Smith Francine Gabriel
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.lb553
Subject(s) - endocrinology , medicine , angiotensin ii , nitric oxide , chemistry , receptor , angiotensin ii receptor type 1 , renin–angiotensin system , angiotensin receptor , hemodynamics , blood pressure
To investigate whether renal haemodynamic effects of nitric oxide (NO) in the newborn are mediated by activation of angiotensin type 1 (AT 1 ) or/and type 2 (AT 2 ) receptors, three experiments were carried out in conscious, chronically instrumented lambs aged ~one (N=5) and ~six weeks (N=6). Measurements were made before and after I.V. administration of antagonists selective to the AT 1 receptor (ZD 7155, experiment 1), the AT 2 receptor (PD 123319, experiment 2), and both receptors (ZD 7155+PD 123319, experiment 3) before and after administration of the L‐arginine analogue, L‐NAME. After ZD 7155 and ZD 7155+PD 123319, but not PD 123319 alone, renal vascular resistance (RVR) decreased in both age groups by ~25%. At one week, the RVR increase after L‐NAME was ~20% with ZD 7155, and ZD 7155 plus PD 123319, and ~16% with PD 123319 alone. At six weeks, the RVR increase after L‐NAME was ~40% with ZD 7155, and ZD 7155+PD 123319, and ~30% with PD 123319 alone. Therefore, ANG II modulates baseline renal haemodynamics as well as the renal haemodynamic effects of NO in an age‐dependent manner, through activation of both AT 1 and AT 2 receptors.