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Growth inhibition effects of human breast cancer cell line by ursolic acid
Author(s) -
Gim GyeongHun,
Choi YounKyung,
Shin YongCheol,
Ko SeongGyu
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.lb496
Subject(s) - ursolic acid , apoptosis , carcinogenesis , tumor promotion , chemistry , breast cancer , cancer , cancer research , pharmacology , biochemistry , traditional medicine , biology , medicine , botany
Growth inhibition effects of human breast cancer cell line by ursolic acid. Gyeong‐Hun. Gim, Youn‐Kyung. Choi, Yong‐Cheol. Shin, Seong‐Gyu. Ko Lab of Clinical Biology and Pharmacogenomics, Department of Basic Science of Oriental Medicine, College of Oriental Medicine, Kyunghee University. Ursolic acid (3‐hydroxy‐urs‐12‐en‐28‐oic acid) is a pentacyclic triterpenoid derived from leaves, berries, fruits, and flowers of medicinal plants, such as Rosemarinus officinalis. Ursolic acid has been shown to inhibit tumorigenesis, tumor promotion, and suppress angiogenesis. Besides, we found that ursolic acid have been shown to decreased cell proliferation and induce apoptosis in a variety of breast cancer cell line (MCF‐7, MDA‐MB‐231, MDA‐MB‐453, SK‐BR‐3). It support that ursolic acid activates apoptosis of breast cancer cell. So It was detected to protein level of genes associated apoptosis signal by using immunoblotting. Among many proteins, caspase‐3 was increased. Therefore, our results explain that ursolic acid led to activates caspase 3 and poly(ADP‐ribose) polymerase cleavage, result in apoptosis activation. These results of ursolic acid could have predicted the possibility as anticancer therapy drug.